Random mutagenesis of human serine racemase reveals residues important for the enzymatic activity
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چکیده
منابع مشابه
Mutagenesis of conserved amino acids of Helicobacter pylori fur reveals residues important for function.
The ferric uptake regulator (Fur) of the medically important pathogen Helicobacter pylori is unique in that it has been shown to function as a repressor both in the presence of an Fe2+ cofactor and in its apo (non-Fe2+-bound) form. However, virtually nothing is known concerning the amino acid residues that are important for Fur functioning. Therefore, mutations in six conserved amino acid resid...
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High levels of D-serine occur in mammalian brain, where it appears to be an endogenous ligand of the glycine site of N-methyl-D-aspartate receptors. In glial cultures of rat cerebral cortex, D-serine is enriched in type II astrocytes and is released upon stimulation with agonists of non-N-methyl-D-aspartate glutamate receptors. The high levels of D-serine in discrete areas of rat brain imply th...
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ژورنال
عنوان ژورنال: Collection of Czechoslovak Chemical Communications
سال: 2010
ISSN: 1212-6950
DOI: 10.1135/cccc2010003